The transformation of contemporary enterprises is a complex and multifaceted process that should be integrated into their development strategy. One of the manifestations of this transformation is the tendency of enterprises to implement and actively use specific software and IT systems, such as extranets, simple spreadsheets and text editors, relational database systems, project management software, remote desktop software, CRM systems, and Business Intelligence systems. The article’s primary objective is to identify the software and IT systems used in innovative enterprises and to assess the overall complexity of this phenomenon from the perspective of Poland’s regions. The basis for the analysis is the division of Poland into regions (created by voivodeships) with various levels of innovation potential. The study used a diagnostic survey. The research technique consists of CAWI interviews con ducted with a random sample of 200 respondents – business owners or managers responsible for computerization/digitization processes, innovation processes, or project management employed in companies operating in Poland’s most innovative sectors. The study covered the entire area of Poland (16 voivodeships). The CAWI questionnaire was based on respondents’ opinions, using a 5-point scale. The study revealed that the specified regions in Poland do not differ statistically in terms of the use of specific software and IT systems. Additionally, the complexity of utilizing software and IT systems in innovation processes is moderately high. The most commonly used IT solutions include email accounts, intranets, simple spreadsheets, simple text editors, and antivirus software.