The dynamically changing operating conditions of modern organizations cause changes in their processes, including project management. It can be observed that, increasingly often, projects are a structured response to problems occurring in the company, especially in the sphere of production and work organization. Therefore, there is a need to determine the factors and conditions that require proper management in order to increase the chances of a successful implementation of a project. This relationship is also recognized in the case of pro-ergonomic projects that implement goals and tasks relating to ergonomics. For this reason, this article addresses the issue of identifying and assessing such factors - those in relation to the way projects are conducted as well as those which concern organizational and safety culture. The main goal of this article is to examine the opinions of experts on the factors which determine the success of pro-ergonomic projects in terms of their importance, and to determine the significance of factors relating to safety culture in comparison. The results of the expert opinion research were analyzed using descriptive statistics and presented in a box-plot chart. The analysis pointed to the conclusion that factors relating to safety culture were assessed by experts as the most important (compared to the factors connected with organization of the project and factors linked to carrying out ergonomic activities in the organization). It can also be stated that the factors relating to organization of the project (usually resulting from the project management methodology adopted) were rated the lowest.