A key priority of the European Union’s employment strategy and Europe 2020 is to create more and better jobs in Europe, while improving their quality and ensuring better working conditions. In order picking “man-to-goods” workplaces automation still will not be rational in the near future. This is an example of a working environment where humans are still central actors and determine their effectiveness and efficiency. Order picking activities are labour-intensive and time-consuming. Researchers have developed models for planning order picking activities and increasing the efficiencies of such systems by suggesting different warehouse layouts, order picking routes or storage assignments. Developed models for planning order picking activities largely ignore workers’ characteristics, or human factors, suggesting that they cannot be substantiated, which leads to only partially realistic results. To fill this obvious gap the authors are trying, with an interdisciplinary approach, to find ways to incorporate human factors into order picking models and improve working conditions in order picking processes with a literature review and survey on employees’ perception of working conditions and health problems.