The aim of this project is to detect human factors and safety issues in road accidents in Iran and eradicate casualties, injuries and damages by improving safety culture and using new technology. Nowadays, nearly 1.24 million people are killed in road accidents every year in the world. Vehicle accidents can be divided into three fundamental categories: 1-accidents caused by human errors, 2- accidents caused by equipment failure and 3- bad road conditions. Safety design and paying adequate attention to human factors can eliminate the root of all these deadly crashes, injuries and musculoskeletal diseases; moreover, it can reduce economic loss due to disabilities caused by accidents. Iran is among the countries which has a high casualty rate due to cultural attitudes towards road rules and poor vehicle safety and facilities. In this project, one Iranian car company named Iran Khodro is chosen and all its aspects of safety design, human factors and production are studied and examined. In addition, some methods and solutions are given with new tested technologies in Europe to deal with human error and lack of safety facilities, e.g., using fatigue device technology to make the driver safe while driving, choosing safe cars for the roads by testing them in Euro NCAP program, etc. to reduce the possibility of accidents and to lower the number of fatalities and injuries and improve overall road safety.