The article focuses on selected issues related to hackathon application in creating open innovation within a cluster. The considerations were based mainly on the case study method, desk research, and a literature review. In addition to the introduction and conclusion, it consists of three parts, which characterize the essence of open innovation, the strategic dimension of the hackathon and the cluster experiences with using of hackathon. Based on the results of own research, it was shown that creating open innovations using a hackathon in clusters not only shapes the investment attractiveness of clusters, but also contributes to the construction of an efficient regional innovation ecosyetm. The article draws attention to the fact that the business and social potential of the hackathon provides a wide range of benefits essential for cluster development. Moreover, it is emphasized that the successful application of the hackathon in process of creating open innovations is an example of a strategic challenge for cluster management in a turbulent environment. The research problem in the field of management and quality sciences, analyzed by the Authors as a part of the article is directly related to the essence of strategic and creative entrepreneurship within knowledge-based economy.